MODEL 2400 PATCH CLAMP AMPLIFIER
LOW NOISE, FULL-FEATURED
Designed for voltage clamping using patch electrodes on single channels or whole cells.The Model 2400 is a low-noise, full-featured patch clamp amplifier designed for voltage clamping using patch electrodes on single channels or whole cells. Its design also allows fast intracellular current clamp measurements with sharp electrodes.Amplifier current gain can be matched to your experimental needs by selecting one of the three available dual resistive feedback probes, as the gain is partially determined by the value of the resistor in the headstage. There are three heastages to choose from: 1 GΩ/10 MΩ, 10 GΩ/10 MΩ, and 10 GΩ/100 MΩ. The wide range of feedback resistors means currents can be recorded with outputs of 1 mV/nA to 10 mV/fA. The standard probe sent with each unit is the 100 M>Ω/10 G>Ω version, but other values can be selected.
Optopatcher Holders
The Optopatcher provides unmatched accuracy in applying optical stimulation to an in-vivo patch-clamp protocol. The holder houses both an optical fiber and an electrode enabling simultaneous patch-clamp recording and optogenetic activation.
This is a significant advantage in non-slice protocols, such as in-vivo recording from intact animals, whole-cell patch-clamping, LFP recording, and spike/single-unit recording.
The optopatcher was developed by A-M Systems under the guidance of its inventors, Dr. Ilan Lampl and Dr. Yonatan Katz of the Weizmann Institute of Science in Israel. (J Neurosci Meth 214 (2013) 113– 117)
